Diagnosis Of Oral Squamous Cell Carcinoma By Raman Spectroscopy

Posted By : Joy

Sep 06, 2021

Category: Raman Blog

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In the current clinical manifestations, oral mucosal lesions require initial conservative treatment and monitoring. If the disease persists, a biopsy will be used for diagnosis. A new study shows that laser Raman spectroscopy can be used to diagnose early oral squamous cell carcinoma in real time. As a common cancer, oral squamous cell carcinoma is not easy to detect, and it is usually found only in the advanced stages of the cancer.

According to the research results of Hamburg Eppendorf University Medical Center, Raman spectroscopy can be used to reveal whether a damaged organ or skin is cancerous in real time. This technology can reduce the detection time and a large number of invasive operations.

What is displacement differential Raman?Shifted Differential Raman Spectroscopy (SERDS), this technology is based on collecting two different spectra in two slightly shifted excitation wavelengths. Ideally, the two spectra are differentially processed, and the obtained differential spectra, The stimulated emission spectrum and the noise background will be completely cancelled out, and what is left is the difference image of the Raman spectrum and its own translation spectrum, and then the Raman spectrum is restored by the denoising and deconvolution algorithm.

Optosky's ATR3020 adopts the international leading differential Raman spectroscopy technology, it has built-in two adjacent wavelength lasers to generate excitation light in time sharing to excite the sample. The Raman signal is very sensitive to the wavelength of the excitation light, while the fluorescence signal is not sensitive. Technology, which can suppress fluorescence, can directly measure highly fluorescent substances, anti-interference, anti-noise, greatly improve the overall detection sensitivity and signal-to-noise ratio of the system, and achieve filtering of interference peaks (such as ambient light peaks, fluorescence peaks, etc.), and only retain.

The pure Raman peak captures tiny signal differences.Because it can better remove various interferences such as fluorescence, the ATR3020 portable Raman spectrometer can also reduce the power requirements of the light source under the premise of ensuring the accuracy, and improve the reliability of the whole machine and the ability of spectral error correction. Through the cooperation with SERS ,the combination of technology can achieve PPB-level detection capability, suitable for outdoor operations.